Application Notes

  Automated buffer exchange during the protein characterization process

Biopharmaceuticals, in particular therapeutic proteins and antibodies, are a steadily growing segment and currently the most successful group of drugs. Due to the chemical and structural variability of the molecules, a thorough characterization is very important. During the characterization of proteins, in many cases a buffer exchange has to be carried out in order to stabilize them or to create the necessary conditions for further processing. With the goal of overcoming the current bottleneck in the automation of quality control of therapeutic proteins, scienova and Hamilton Robotics have joined forces to automate scienova’s Xpress dialyzer plates on Hamilton’s Microlab STAR.

The results speak for themselves and for the pursuit of this approach. The Xpress Dialyzer plates are an ideal tool for automated exchange of the dialysis buffer.


Automation of the scienova Micro Dialyzer MD100 GridKit48 on CyBi®-FeliX

Fully automated handling of scienova Xpress Micro Dialyzer with Analytik Jena‘s liquid handling device Cybio®FeliX.



Protein dialysis with automated liquid handling devices

Protein renaturation and equilibrium dialysis with fully automated liquid handling and SBS compatible microdialysis devices

Biocellulose – A new type of separation membrane


"Development of a utilization strategy for scienova's Xpress Dialyzer products "funded by the Free State of Thuringia from the European Social Fund