Efficient All-in-One Dialysis for Small Sample Volumes
The Xpress Dialyzers™ from scienova are ready-to-use, innovative all-in-one dialysis systems specifically designed for gentle and efficient purification of small sample volumes between 10 µl and 19 ml. Thanks to their optimized geometry, they offer short dialysis times and high sample recovery rates of up to 98%.
With molecular weight cut-offs (MWCO) ranging from 2 to 140 kDa, Xpress Dialyzers™ are highly versatile—ideal for protein, RNA, and DNA purification, equilibrium dialysis, and the removal of unwanted substances after protein synthesis.
The systems support both manual and automated applications, are fully compatible with liquid handling systems (SBS format), and enable scalable processing of up to 96 samples simultaneously—perfect for single tests and high-throughput workflows alike. Their SBS microplate format compatibility allows for convenient sample handling with multichannel pipettes.
Xpress Dialyzers™ are also used in drug development, such as in protein binding studies and clinical diagnostics for the preparation of free hormones like testosterone, cortisol, FT3, and FT4, or in cell-free protein synthesis.
Combining precision, flexibility, and process reliability, Xpress Dialyzers™ are the optimal solution for modern laboratory dialysis workflows.
| Dialyzer Version | Sample Volume |
|---|---|
| Micro Dialyzer MD100 | 10–100 µl |
| Micro Dialyzer MD300 | 50–300 µl |
| Equilibrium Dialyzer ED300 | 50–300 µl |
| Mini Dialyzer MD1000 | 150–1000 µl |
| Xpress Dialysis Reactor XDR | 1–19 ml |
Depending on the application, the dialyzers are available in various formats:
They can be used in deep-well plates, a dialysis box (XDB), or in sample tubes with integrated buffer reservoirs. This flexibility allows seamless integration into both manual and automated laboratory workflows.
Xpress Dialyzers in the Shop
Applications
- Protein purification:
– Desalting, buffer exchange, dye removal, and sample concentration (e.g., after protein synthesis) - Protein denaturation/renaturation:
– Removal of urea, guanidine hydrochloride, ammonium sulfate - Nanoparticle purification
- Equilibrium dialysis:
– Hormone analysis (e.g., testosterone)
– Drug interaction and binding studies - Cell-free protein synthesis
Advantages
- High sample throughput with up to 2–12x faster analysis and preparation times
- High yield with up to 98% sample recovery
- Optimized for liquid-handling systems using SBS microplate format
- Easy sample loading and recovery with standard or multichannel pipettes
- Largely autoclavable – allows for easy and reliable sterilization
Laboratory Sample Dialysis – Efficient, Gentle, Automatable
Efficient Sample Purification
Xpress Dialyzers from scienova are ready-to-use dialysis systems for small sample volumes. They allow fast, efficient, and gentle purification of protein, RNA, and DNA samples—with significantly higher sample recovery compared to ultrafiltration or chromatography.
Optimized Geometry
Their special cartridge design with an ideal membrane surface-to-volume ratio and short diffusion path reduces dialysis time and improves exchange and interaction efficiency.
Ready-to-Use & User-Friendly
Designed in a convenient cartridge format, Xpress Dialyzers are ready-to-use and can be easily handled using standard laboratory pipettes.
Typical Applications
Ideal for purifying protein samples after tryptic digestion (e.g., for LC/MS analyses) or removal of unwanted substances after protein synthesis
Automation & High-Throughput
Compatible with SBS microplate format and suitable for pipetting robots and lab automation systems—perfect for high-throughput screening and scouting assays.
Equilibrium Dialysis for Research
Excellent for interaction and binding studies in pharmaceutical development or diagnostics of free hormones (e.g., testosterone) using equilibrium dialysis.
Efficiency & Cost-Effectiveness
scienova’s modern dialysis technology conserves resources, increases cost-efficiency, and offers a superior alternative to traditional dialysis tubing—especially for small sample volumes and high sample numbers.
